Downward, Julian: search on Z-Library

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1

Flicking the Warburg Switch—Tyrosine Phosphorylation of Pyruvate Dehydrogenase Kinase Regulates Mitochondrial Activity in Cancer Cells

Almut Schulze, Julian Downward

Journal:

Year:

2011

Language:

english

File:

PDF, 251 KB

english, 2011

2

Exchange rate mechanisms

Downward, Julian

Journal:

Year:

1992

File:

PDF, 276 KB

1992

3

PI 3-kinase, Akt and cell survival

Julian Downward

Journal:

Seminars in Cell & Developmental Biology

Year:

2004

Language:

english

File:

PDF, 140 KB

english, 2004

4

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

Fritsch, Ralph, de Krijger, Inge, Fritsch, Kornelia, George, Roger, Reason, Beth, Kumar, Madhu S., Diefenbacher, Markus, Stamp, Gordon, Downward, Julian

Journal:

Year:

2013

Language:

english

File:

PDF, 3.86 MB

english, 2013

5

Targeting RAS signalling pathways in cancer therapy

Downward, Julian

Journal:

Nature Reviews Cancer

Year:

2003

Language:

english

File:

PDF, 1.49 MB

english, 2003

6

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Miess, Heike, Dankworth, Beatrice, Gouw, Arvin M., Rosenfeldt, Mathias, Schmitz, Werner, Jiang, Ming, Saunders, Becky, Howell, Michael, Downward, Julian, Felsher, Dean W., Peck, Barrie, Schulze, Almut

Journal:

Year:

2018

Language:

english

File:

PDF, 1.89 MB

english, 2018

7

SnapShot: Class I PI3K Isoform Signaling

Fritsch, Ralph, Downward, Julian

Journal:

Year:

2013

Language:

english

File:

PDF, 323 KB

english, 2013

8

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

RodrÃguez-MartÃnez, Marta, BoissiÃ©re, Thierry, Gonzalez, Melvin Noe, Litchfield, Kevin, Mitter, Richard, Walker, Jane, KjÅr, Svend, Ismail, Mohamed, Downward, Julian, Swanton, Charles, Svejstrup,

Journal:

Year:

2020

File:

PDF, 2.12 MB

2020

9

Ras regulation: putting back the GTP

Julian Downward

Journal:

Current Biology

Year:

1992

Language:

english

File:

PDF, 527 KB

english, 1992

10

The GTPase superfamily (Ciba foundation symposium 176): edited by Joan Marsh and Jamie Goode, John Wiley, 1993, £45.00 (289 pages) ISBN 0 471 93914 5

Julian Downward

Journal:

Trends in Cell Biology

Year:

1994

Language:

english

File:

PDF, 149 KB

english, 1994

11

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

Warne, Patricia H., Vician, Pablo Rodrigueza, Downward, Julian

Journal:

Year:

1993

File:

PDF, 529 KB

1993

12

p110δ , a Novel Phosphoinositide 3-Kinase in Leukocytes

Bart Vanhaesebroeck, Melanie J. Welham, Kei Kotani, Rob Stein, Patricia H. Warne, Marketa J. Zvelebil, Kyoichiro Higashi, Stefano Volinia, Julian Downward and Michael D. Waterfield

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.95 MB

english, 1997

13

Ras and TGFβ Cooperatively Regulate Epithelial Cell Plasticity and Metastasis: Dissection of Ras Signaling Pathways

Elzbieta Janda, Kerstin Lehmann, Iris Killisch, Martin Jechlinger, Michaela Herzig, Julian Downward, Hartmut Beug and Stefan Grünert

Journal:

The Journal of Cell Biology

Year:

2002

Language:

english

File:

PDF, 5.91 MB

english, 2002

14

Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

Calleja, Véronique, Alcor, Damien, Laguerre, Michel, Park, Jongsun, Vojnovic, Borivoj, Hemmings, Brian A., Downward, Julian, Parker, Peter J., Larijani, Banafshé

Journal:

Year:

2007

Language:

english

File:

PDF, 1.44 MB

english, 2007

15

Identification of a Nucleotide Exchange-Promoting Activity for p21ras

Julian Downward, Rebecca Riehl, Ling Wu and Robert A. Weinberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.04 MB

english, 1990

16

CUTL1: A Key Mediator of TGFβ-Induced Tumor Invasion

Michl, Patrick, Downward, Julian

Journal:

Year:

2006

Language:

english

File:

PDF, 410 KB

english, 2006

17

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Castellano, Esther, Molina-Arcas, Miriam, Krygowska, Agata Adelajda, East, Philip, Warne, Patricia, Nicol, Alastair, Downward, Julian

Journal:

Nature Communications

Year:

2016

Language:

english

File:

PDF, 1.47 MB

english, 2016

18

A target for Pl(3) kinase

Downward, Julian

Journal:

Year:

1995

File:

PDF, 585 KB

1995

19

Identification of the Ras GTPase-activating protein GAP1m as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo

Peter J. Lockyer, Stefan Wennström, Sabine Kupzig, Kanamarlapudi Venkateswarlu, Julian Downward, Peter J. Cullen

Journal:

Current Biology

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

20

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

Wood-Kaczmar, Alison, Gandhi, Sonia, Yao, Zhi, Abramov, Andrey S. Y., Miljan, Erik A., Keen, Gregory, Stanyer, Lee, Hargreaves, Iain, Klupsch, Kristina, Deas, Emma, Downward, Julian, Mansfield, Louise

Journal:

Year:

2008

Language:

english

File:

PDF, 793 KB

english, 2008

21

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

Kumar, Madhu S., Armenteros-Monterroso, Elena, East, Philip, Chakravorty, Probir, Matthews, Nik, Winslow, Monte M., Downward, Julian

Journal:

Year:

2013

Language:

english

File:

PDF, 6.16 MB

english, 2013

22

Role of receptor tyrosine kinases in G-protein-coupled receptor regulation of Ras: transactivation or parallel pathways?

DOWNWARD, Julian

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 49 KB

english, 2003

23

HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

Raz, Richard, Burlina, Fabienne, Ismail, Mohamed, Downward, Julian, Li, Jiejin, Smerdon, Stephen J., Quibell, Martin, White, Peter D., Offer, John

Journal:

Angewandte Chemie

Year:

2016

Language:

english

File:

PDF, 1.60 MB

english, 2016

24

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer

Murillo, Miguel M., Rana, Sareena, Spencer-Dene, Bradley, Nye, Emma, Stamp, Gordon, Downward, Julian

Journal:

Year:

2018

Language:

english

File:

PDF, 3.31 MB

english, 2018

25

Transfer of functional EGF receptors to an IL3-dependent cell line

Mary K. L. Collins, Julian Downward, Atsushi Miyajima, Kazuo Maruyama, Ken-Ichi Arai, Richard C. Mulligan

Journal:

Journal of Cellular Physiology

Year:

1988

Language:

english

File:

PDF, 655 KB

english, 1988

26

Plugging the GAPs

Julian Downward

Journal:

Current Biology

Year:

1991

Language:

english

File:

PDF, 456 KB

english, 1991

27

Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell–matrix and cell–cell interaction

Sandra J. Watton, Julian Downward

Journal:

Current Biology

Year:

1999

Language:

english

File:

PDF, 97 KB

english, 1999

28

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

László Buday, Julian Downward

Journal:

Year:

1993

Language:

english

File:

PDF, 1.66 MB

english, 1993

29

Mutant KRAS at the Heart of Tumor Immune Evasion

van Maldegem, Febe, Downward, Julian

Journal:

Year:

2020

File:

PDF, 726 KB

2020

30

RNA interference-based functional genomics in cancer research – an introduction

Downward, Julian

Journal:

Year:

2004

Language:

english

File:

PDF, 63 KB

english, 2004

31

Mechanisms and consequences of activation of protein kinase B/Akt

Julian Downward

Journal:

Current Opinion in Cell Biology

Year:

1998

Language:

english

File:

PDF, 588 KB

english, 1998

32

Ras signalling and apoptosis

Julian Downward

Journal:

Current Opinion in Genetics & Development

Year:

1998

Language:

english

File:

PDF, 560 KB

english, 1998

33

p21ras-Induced Responsiveness of Phosphatidylinositol Turnover to Bradykinin is a Receptor Number Effect

Julian Downward, Jean De Gunzburg, Rebecca Riehl and Robert A. Weinberg

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 885 KB

english, 1988

34

Growth and maturation factors, volume 2, G. Guroff (Ed.), John Wiley & Sons, Chichester, 1984. xiii + 340 pp. incl. index. Price: £66. ISBN 0 471 09708 X

Julian Downward

Journal:

Hematological Oncology

Year:

1985

Language:

english

File:

PDF, 65 KB

english, 1985

35

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

Hallberg, Bengt, Ashcroft, Margaret, Loeb, David M, Kaplan, David R, Downward, Julian

Journal:

Year:

1998

Language:

english

File:

PDF, 345 KB

english, 1998

36

Many faces of Ras activation

László Buday, Julian Downward

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2008

Language:

english

File:

PDF, 745 KB

english, 2008

37

CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness

Patrick Michl, Antoine R. Ramjaun, Olivier E. Pardo, Patricia H. Warne, Martin Wagner, Richard Poulsom, Corrado D’Arrigo, Kenneth Ryder, Andre Menke, Thomas Gress, Julian Downward

Journal:

Year:

2005

Language:

english

File:

PDF, 681 KB

english, 2005

38

Finding the Weakness in Cancer

Downward, Julian

Journal:

Boston Medical and Surgical Journal

Year:

2009

Language:

english

File:

PDF, 474 KB

english, 2009

39

RAS mutation status and bortezomib therapy for relapsed multiple myeloma

Smith, Dean, Armenteros, Elena, Percy, Laura, Kumar, Madhu, Lach, Anna, Herledan, Gaelle, Stubbs, Matthew, Downward, Julian, Yong, Kwee

Journal:

British Journal of Haematology

Year:

2015

Language:

english

File:

PDF, 173 KB

english, 2015

40

Interaction of Ras with phosphoinositide 3-kinase γ

RUBIO, Ignacio, RODRIGUEZ-VICIANA, Pablo, DOWNWARD, Julian, WETZKER, Reinhard

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 290 KB

english, 1997

41

[Methods in Enzymology] Small GTPases and Their Regulators, Part A: RAS Family Volume 255 || [11] Measurement of nucleotide exchange and hydrolysis activities in immunoprecipitates

Downward, Julian

Year:

1995

Language:

english

File:

PDF, 358 KB

english, 1995

42

Trachealess—A New Transcription Factor Target for PKB/Akt

Julian Downward, Sally J. Leevers

Journal:

Developmental Cell

Year:

2001

Language:

english

File:

PDF, 81 KB

english, 2001

43

SPIE Proceedings [SPIE SPIE Medical Imaging - San Diego, California, USA (Saturday 15 February 2014)] Medical Imaging 2014: Computer-Aided Diagnosis - Automated segmentation of murine lung tumors in x-ray micro-CT images

Aylward, Stephen, Hadjiiski, Lubomir M., Swee, Joshua K. Y., Sheridan, Clare, de Bruin, Elza, Downward, Julian, Lassailly, Francois, Pizarro, Luis

Year:

2014

Language:

english

File:

PDF, 770 KB

english, 2014

44

Protein Kinase B Activation and Lamellipodium Formation Are Independent Phosphoinositide 3-Kinase-Mediated Events Differentially Regulated by Endogenous Ras

van Weering, David H. J., de Rooij, Johan, Marte, Barbara, Downward, Julian, Bos, Johannes L., Burgering, Boudewijn M. T.

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.42 MB

english, 1998

45

The regulation and function of p21ras in T cells

Julian Downward, Jonathan Graves, Doreen Cantrell

Journal:

Immunology Today

Year:

1992

Language:

english

File:

PDF, 404 KB

english, 1992

46

Stimulation of p21ras upon T-cell activation

Downward, Julian, Graves, Jonathan D., Warne, Patricia H., Rayter, Sydonia, Cantrell, Doreen A.

Journal:

Year:

1990

File:

PDF, 494 KB

1990

47

The ins and outs of signalling

Downward, Julian

Journal:

Year:

2001

Language:

english

File:

PDF, 368 KB

english, 2001

48

Cell biology: Metabolism meets death

Downward, Julian

Journal:

Year:

2003

Language:

english

File:

PDF, 231 KB

english, 2003

49

Use of RNA interference libraries to investigate oncogenic signalling in mammalian cells

Downward, Julian

Journal:

Year:

2004

Language:

english

File:

PDF, 130 KB

english, 2004

50

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Kathrin S. Zeller, Olof Idevall-Hagren, Anne Stefansson, Teet Velling, Shaun P. Jackson, Julian Downward, Anders Tengholm, Staffan Johansson

Journal:

Cellular Signalling

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

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